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Prostate Health Info

Organic Lignan Extract + Low Fat Diet = Better Prostate Health 

In a recent study at the Division of Urologic Surgery at Duke University, 25 prostate cancer patients were placed on a short term (34 days average) low-fat diet supplemented with flaxseed and its lignan component.  The researchers reported differences in the biology of the tumors. "Tumor cells (of men on the diet and supplementation) did not divide as quickly and there was a greater rate of apoptosis (tumor cell reduction) in this group," noted Dr. Demark-Wahnefried - lead researcher

The Research on Lignans and Prostate Health
      Prostate cancer is the second most commonly diagnosed form of cancer and the No. 2 cause of cancer death among U.S. men, according to the American Cancer Society. It is estimated that 200,000 new cases of prostate cancer will be diagnosed and 32,000 men will die of it in 2002. By age 50, 15 to 30 percent of men already have some cancer cells present within the prostate gland. Keeping DHT levels in check is considered to be an important step in preventing those cancer cells from dividing and spreading en masse throughout the prostate gland and metastasizing to other parts of the body. Thus, the ingestion of lignans on a daily basis provides important bioactive agents that indirectly slow the rate of prostate cell division, reducing the chances of prostate enlargement (benign prostatic hyperplasia) and hindering the promotion of cancer development. Phytoestrogens, such as lignans, also bind to receptors on the prostate gland helping to block the influence of other hormones, which may stimulate rapid prostate cell division. Prostate cancer is the most common cancer in men and prostate enlargement problems will affect 80 percent of men if they live to old age.
      Although there are highly invasive treatments for prostate cancer, more and more studies are being conducted on natural treatments that may prove to be effective with little or no side effects. Studies also indicate that lignan supplements may also add to the benefit of conventional treatments. The below information is on some of the more prevalent studies conducted on lignans and prostate cancer.
     Also, see the below links on prostate cancer and lignans in the news.
 

 
Scientific Research Articles Regarding Lignans

CLINICAL TRIAL- Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 2001 Jul;58(1):47-52

Effect of mammalian lignans on the growth of prostate cancer cell lines. Anticancer Research 2001 Nov-Dec;21(6A):3995-9

Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. Journal of Biological Chemistry 2001 Apr 20;276(16):12614-23

Phytoestrogens and diseases of the prostate gland. Baillieres Clin Endocrinol Metab 1998 Dec;12(4):625-47

Certain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogenesis of prostate cancer.Eur Urol 1999;35(5-6):443-55

Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids.J Endocrinol 1995 Nov;147(2):295-302

Phyto-oestrogens and Western diseases.Ann Med. 1997 Apr;29(2):95-120. Review.

Prostate & Lignan News on the Web

Cancer Research Foundation of America

WebMD

Science Daily

MSNBC News

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